Attenuation of haloperidol-induced catalepsy by a 5-HT2Creceptor antagonist
نویسندگان
چکیده
منابع مشابه
Piracetam reverses haloperidol-induced catalepsy in mice
Results: Th e administration of haloperidol (2 mg/kg, IP) resulted in signifi cant catalepsy. Piracetam (in dosages of 50, 100, and 300 mg/kg) given IP at the time of haloperidol administration reduced the duration of catalepsy by 24.4%, 32.3%, and 48.2%, respectively. Piracetam given as a 30-min pretreatment reduced the duration of catalepsy by 59.5%, 72.3%, and 78.2%, respectively. Vinpocetin...
متن کاملEffect of Tribulus terrestris on Haloperidol-induced Catalepsy in Mice
Haloperidol, an antipsychotic drug, leads to the development of a behavioural state called catalepsy, in which the animal is not able to correct an externally imposed posture. In the present study we have attempted to evaluate the anticataleptic effect of Tribulus terrestris on haloperidol-induced catalepsy in albino mice. Mice were allocated to four groups, each group containing six animals. B...
متن کاملEffects of 5-HT in globus pallidus on haloperidol-induced catalepsy in rats.
Histological, behavioral and electrophysiological studies have suggested that 5-HT may regulate motor function by affecting globus pallidus neurons activity. In this study, the effects of 5-HT in globus pallidus on haloperidol-induced catalepsy and its possible receptor mechanisms were examined in rats using bar tests. Bilateral microinjection of 5-HT (10microM) into globus pallidus significant...
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introduction : tardive dyskinesia is one of the major side effects of long-term neuroleptic treatment. increased reactive oxygen species and oxidative stress has been proposed as possible etiopathologic mechanisms. ginkgo biloba extract (egb) is a natural antioxidant. we investigated the effects of ginkgo biloba extract on neuroleptic-induced orofacial dyskinesia in rats, a potential animal mod...
متن کاملEarly life stress causes refractoriness to haloperidol-induced catalepsy.
The use of classic antipsychotic drugs is limited by the occurrence of extrapyramidal motor symptoms, which are caused by dopamine (DA) receptor blockade in the neostriatum. We examined the impact of early-life stress on haloperidol-induced catalepsy using the rat model of prenatal restraint stress (PRS). Adult "PRS rats," i.e., the offspring of mothers exposed to restraint stress during pregna...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1999
ISSN: 0007-1188,1476-5381
DOI: 10.1038/sj.bjp.0702350